Hydrochloric Acid → 4-Hydroxy-2-methoxybenzoic acid

HRID 1672

반응식

HRID 1672 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1.O.O[Li].O.Cl>C1COCC1>[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:12][CH3:13])[CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 12532676Methyl 4-hydroxy-2-methoxybenzoate

생성물 1

HCID 126955754-Hydroxy-2-methoxybenzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of methyl 4-hydroxy-2-methoxybenzoate (11 g, 60 mmol) in THF:H2O (100 mL:10 mL) was added LiOH.H2O (3 g, 71 mmol). The solution was stirred over 24 h and then made slightly acidic (pH 5) with 10% HCl (approx 15 mL). The reaction solution was extracted with CH2Cl2 (3×50 mL). The organic phase was dried (MgSO4) and filtered. The solvent was evaporated under reduced pressure to afford the 4-hydroxy-2-methoxybenzoic acid as a clean white foam.

후처리

  1. extractionThe reaction solution was extracted with CH2Cl2 (3×50 mL)
  2. dry with materialThe organic phase was dried (MgSO4)
  3. filtrationfiltered
  4. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-c1656a56b0b84177904d3a04b5264874
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726172

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