Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid

HRID 1672477

반응식

HRID 1672477 반응식
C(N[C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9])(=O)C.[OH-:18].[K+].Cl>O>[OH:18][C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2434333-Acetamido-4-methyl-2-nitrobenzoic acid

생성물 1

HCID 813743-Hydroxy-4-methyl-2-nitrobenzoic acid수율 93.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.

후처리

  1. temperatureThe dark red solution was cooled
  2. filtrationThe yellow solid was filtered
  3. customre-crystallized from water (1800 mL)

출처 및 근거

ORD 기록
ord-38c31f1419744cd699942a50b6d9a0af
출처 데이터셋
uspto-grants-2011_08
특허 번호
US07998978B2

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