Hydrochloric Acid → 3,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid

HRID 1675567노트

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HRID 1675567 반응식
[CH2:1]([O:4][C:5]1[C:16]([O:17][CH3:18])=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:19][CH3:20])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[C:6]([O:19][CH3:20])=[CH:7][C:8]([C:9]([OH:11])=[O:10])=[CH:15][C:16]=1[O:17][CH3:18])[C:2]#[CH:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017922-Propynyl 4-(2-propynyloxy)-3,5-dimethoxybenzoate

생성물 1

HCID 131214813,5-Dimethoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid수율 97.4%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To 50 ml of methanol were added 15.5 g of 2-propynyl 4-(2-propynyloxy)-3,5-dimethoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at 50° C. for 4 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was made acidic by addition of hydrochloric acid. The precipitated crystals were collected by filtration, and dried, and 13.0 g of 4-(2-propynyloxy)-3,5-dimethoxybenzoic acid was obtained.

후처리

  1. temperatureto cool to near room temperature
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-90fc2e508923459780678596902922f9
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003699B2

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