Hydrochloric Acid → 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid

HRID 1675570노트

반응식

HRID 1675570 반응식
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017652-Propynyl 4-(2-propynyloxy)-3-methoxybenzoate

생성물 1

HCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acid수율 107.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of a 15% aqueous sodium hydroxide solution, and the resulting mixture was stirred at room temperature for 8 hours, and then at 50° C. for 2 hours. Thereafter, the reaction mixture which had been allowed to cool to near room temperature was added to hydrochloric acid to make the mixture acidic. The precipitated crystals were collected by filtration, and dried, and 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid was obtained.

후처리

  1. waitat 50° C. for 2 hours
  2. temperatureto cool to near room temperature
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-dadb5c4102d040e59fa5bc8703307617
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08003699B2

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