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Hydrochloric Acid → 2-(4-(2-(1-(Tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinic acid

HRID 1676411
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HRID 1676411 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[O:23][C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:31]4[N:41]=[CH:40][CH:39]=[CH:38][C:32]=4[C:33]([O:35]CC)=[O:34])=[CH:26][C:25]=3[F:42])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[S:22][C:21]3[C:16](=[N:17][CH:18]=[CH:19][C:20]=3[O:23][C:24]3[CH:29]=[CH:28][C:27]([NH:30][C:31]4[N:41]=[CH:40][CH:39]=[CH:38][C:32]=4[C:33]([OH:35])=[O:34])=[CH:26][C:25]=3[F:42])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67345485Ethyl 2-(4-(2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinate

생성물 1

HCID 673485102-(4-(2-(1-(Tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinic acid

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

A round-bottomed flask was charged with ethyl 2-(4-(2-(1-(tert-butoxycarbonyl)piperidin-4-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)nicotinate (0.100 g, 0.169 mmol) and THF (1 mL). NaOH (3.0 mL, 1N) was added and the mixture stirred for 1 hour. The mixture was then acidified to pH 6 with HCl aq. (1N) and extracted with EtOAc. The organics were dried (MgSO4), filtered and concentrated to get product as a yellow solid. LRMS (esi+) 565 m/z (M+1) detected.

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organics were dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customto get product as a yellow solid

출처 및 근거

ORD 기록
ord-316f2e0fbc2f4b8faafa63954fc5c86f
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08003662B2

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