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Hydrochloric Acid → HCID 59540829, 화합물

HRID 1677363
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HRID 1677363 반응식
C([O:3][C:4]([C:6]1[C:14]2[C:9](=[N:10][CH:11]=[C:12]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[N:13]=2)[N:8]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:7]=1[CH3:35])=[O:5])C.[OH-].[Na+].Cl>C1COCC1>[CH3:35][C:7]1[N:8]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:34])[CH3:33])[C:9]2=[N:10][CH:11]=[C:12]([C:15]3[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=3)[N:13]=[C:14]2[C:6]=1[C:4]([OH:5])=[O:3]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59540559HCID 59540559, 화합물

생성물 1

HCID 59540829HCID 59540829, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
60 °C

실험 절차

To a solution of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ethyl ester (110 mg, 0.22 mmol) in 1.0 mL of THF was added a 500 uL of 5.0 M aqueous NaOH. Heated to 60° C. for 3 days. Diluted with THF, made acidic with 1.0 M HCl and partitioned into methylene chloride. Dried the organic phase over Na2SO4, filtered, and concentrated. Collect 107 mg of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid sufficiently pure for the next step.

후처리

  1. custompartitioned into methylene chloride
  2. dry with materialDried the organic phase over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customCollect 107 mg of 6-Methyl-2-(3,4,5-trimethoxy-phenyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid sufficiently pure for the next step

출처 및 근거

ORD 기록
ord-07fc352071ce478aa98eee323e962964
출처 데이터셋
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08008298B2

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