Hydrochloric Acid → 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

HRID 1677678노트

반응식

HRID 1677678 반응식
C[O:2][C:3]([C:5]1[C:6]2[CH:7]=[N:8][N:9]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[C:10]=2[CH:11]=[CH:12][CH:13]=1)=[O:4].[OH-].[Na+].Cl>O.CO>[F:20][C:17]1[CH:16]=[CH:15][C:14]([N:9]2[C:10]3[CH:11]=[CH:12][CH:13]=[C:5]([C:3]([OH:4])=[O:2])[C:6]=3[CH:7]=[N:8]2)=[CH:19][CH:18]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 581388911-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid methyl ester

생성물 1

HCID 581387741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

To a stirred solution of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid methyl ester (2.0 g, 7.4 mmol) in water (20 mL) and methanol (20 mL) was added a solution of 2 N sodium hydroxide (10 mL). The solution was warmed at reflux for 1 hour. The solution was cooled to room temperature and acidified with 1 N aqueous HCl (pH=3-4). The white solid was obtained by filtration, washed with MeOH (30 mL) and dried to afford 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid.

후처리

  1. temperatureThe solution was warmed
  2. temperatureat reflux for 1 hour
  3. customThe white solid was obtained by filtration
  4. washwashed with MeOH (30 mL)
  5. customdried

출처 및 근거

ORD 기록
ord-1e4ca33a18ea4fe28557310c16b39b99
출처 데이터셋
uspto-grants-2011_08
특허 번호
US08008327B2

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