Hydrochloric Acid → 1-Propyl-1H-imidazole-4-carboxylic acid
반응식
[CH2:1]([N:4]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[N:6]=[CH:5]1)[CH2:2][CH3:3].[Li+].[OH-].Cl>CO>[CH2:1]([N:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[N:6]=[CH:5]1)[CH2:2][CH3:3]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of 25-2 (0.6 g, 3.6 mmol) in anhydrous MeOH (2 ml) was added 3N LiOH (2.6 ml, 7.9 mmol). The reaction mixture was heated at 80° C. for 1 h. The heat was reduced and the mixture was stirred at 40° C. overnight. The reaction was then neutralized with 12N HCl and subsequently concentrated in vacuo. The residue was dried azeotropically with toluene to afford the desired product 25-3 as a solid. MS calculated M+H, 155.2. Found 155.1
후처리
- concentrationsubsequently concentrated in vacuo
- dry with materialThe residue was dried azeotropically with toluene
출처 및 근거
- ORD 기록
- ord-02b8e885e986433cb45f3666221e847b
- 출처 데이터셋
- uspto-grants-2011_08
- 특허 번호
- US08008317B2
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