Methanethiol → 2-Chloro-6-(methylsulfanyl)pyrazine

HRID 1679661노트

반응식

HRID 1679661 반응식
[Na].[H-].[Na+].[CH3:4][SH:5].[Cl:6][C:7]1[CH:12]=[N:11][CH:10]=[C:9](Cl)[N:8]=1>C1C=CC=CC=1>[Cl:6][C:7]1[CH:12]=[N:11][CH:10]=[C:9]([S:5][CH3:4])[N:8]=1

참가 물질

6

반응물 4

HCID 878MethanethiolHCID 24758Sodium hydrideHCID 785042,6-DichloropyrazineHCID 5360545Sodium

생성물 1

HCID 203616852-Chloro-6-(methylsulfanyl)pyrazine

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 0.13 mole of sodium methylmercaptide (prepared from 3.12 g. sodium hydride and excess methyl mercaptan), 20 g. (0.13 mole) of 2,6-dichloropyrazine and 200 ml. benzene is heated at reflux for 24 hours, cooled and washed twice with 50 ml. water. The benzene layer is separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Distillation of the residue gives 2-chloro-6-methylthiopyrazine.

후처리

  1. temperatureat reflux for 24 hours
  2. temperaturecooled
  3. washwashed twice with 50 ml
  4. customThe benzene layer is separated
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. distillationDistillation of the residue

출처 및 근거

ORD 기록
ord-51ce95e9ccca438d8bee797a9daa1d48
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04081542

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