Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

HRID 1679676노트

반응식

HRID 1679676 반응식
[C:1]([C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)#[N:2].B#B.Cl>O1CCCC1>[ClH:12].[NH2:2][CH2:1][C:3]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:12])=[CH:11][C:5]=2[C:4]=1[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 227634675-Chloro-3-phenyl-1-benzofuran-2-carbonitrile

생성물 1

HCID 22763506(5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Treat 2.0 g. of 2-cyano-5-chloro-3-phenylbenzo[b]furan (0.008 mole) in 30 ml. of tetrahydrofuran with 18 ml. of diborane in tetrahydrofuran (1 M solution) and reflux for 2 hours. Cool, add 10 ml. of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness and dissolve the residue in 50 ml. of ethanol. Add 30 ml. of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.

후처리

  1. additionTreat 2.0 g
  2. temperatureCool
  3. additionadd 10 ml
  4. customEvaporate the solution to dryness
  5. dissolutiondissolve the residue in 50 ml
  6. additionAdd 30 ml
  7. customDry the precipitate
  8. customobtained

출처 및 근거

ORD 기록
ord-cf457f7b0ccc4728ac007292c0efcc4d
출처 데이터셋
uspto-grants-1978_03
특허 번호
US04081549

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