Ethyl Acetoacetate → Butanoic acid, 3-[[5-(acetylamino)-2-methoxyphenyl]amino]-, ethyl ester

HRID 1679814

반응식

HRID 1679814 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([NH:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:6][C:5]=1[O:14][CH3:15])([O-])=O.[C:16]([O:22][CH2:23][CH3:24])(=[O:21])[CH2:17][C:18]([CH3:20])=O.[H][H]>[Pt].C1(C)C=CC(S(O)(=O)=O)=CC=1.C(O)(C)C>[CH3:15][O:14][C:5]1[CH:6]=[CH:7][C:8]([NH:10][C:11](=[O:13])[CH3:12])=[CH:9][C:4]=1[NH:1][CH:18]([CH3:20])[CH2:17][C:16]([O:22][CH2:23][CH3:24])=[O:21]

참가 물질

7

반응물 3

HCID 8868Ethyl AcetoacetateHCID 950434'-Methoxy-3'-nitroacetanilideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 172818Butanoic acid, 3-[[5-(acetylamino)-2-methoxyphenyl]amino]-, ethyl ester수율 98%

시약·촉매·용매 3

HCID 6101p-Toluenesulfonic acid촉매HCID 23939Platinum촉매HCID 3776Isopropanol용매

실험 절차

A mixture of 105.0 g (0.5 mole) of 2-nitro-4-acetamidoanisole, 67.0 g (0.5 mole) of ethyl acetoacetate, 550 ml of isopropyl alcohol, 10.0 g of 5% Pt/C, and 3.0 g of p-toluenesulfonic acid is treated in an autoclave at 165° C. with 1,000 psi of hydrogen until the uptake of hydrogen ceases. The solvent and catalyst are removed. Upon standing, 143.8 g (98%) of ethyl 3-(2'-methoxy-5-acetamidophenylamino)butyrate is obtained.

후처리

  1. customThe solvent and catalyst are removed

출처 및 근거

ORD 기록
ord-6bb05109ad8a49c986962a820373d6b6
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04271071

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