Hydrochloric Acid → 4,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

HRID 1681297

반응식

HRID 1681297 반응식
F[C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[CH:4]=[C:5]1[S:9]C(=S)N[C:6]1=[O:11].[OH-:20].[Na+].Cl>O>[F:19][C:12]1[C:3]2[CH:4]=[C:5]([C:6]([OH:20])=[O:11])[S:9][C:2]=2[C:15]([F:16])=[C:14]([F:17])[C:13]=1[F:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49072912,3,4,5,6-Pentafluorobenzylidene rhodanine

생성물 1

HCID 109886834,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

78 g of 2,3,4,5,6-pentafluorobenzylidene rhodanine were added in small portions to a stirred solution of 68 g of NaOH in 300 ml of water. The resultant clear red solution was heated to 90° C. for one hour, cooled in ice, acidified with concentrated HCl, and the cream coloured solid which was produced was filtered and washed. The crude product (59 g) was purified by sublimation to give 4,5,6,7-tetrafluorobenzothiophen-2-carboxylic acid having a melting point of 200° C.

후처리

  1. temperaturecooled in ice
  2. customwas produced
  3. filtrationwas filtered
  4. washwashed
  5. customThe crude product (59 g) was purified by sublimation

출처 및 근거

ORD 기록
ord-037c9a762c0c4634b5d80f423aff29cb
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05169983

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