Carbon tetrabromide → Methyl 2-bromo-2-(thiophen-3-yl)acetate

HRID 1681329노트

반응식

HRID 1681329 반응식
O[CH:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:32]>C(#N)C>[Br:32][CH:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromide2회HCID 11776Triphenylphosphine2회HCID 19806271HCID 19806271, 화합물

생성물 1

HCID 19806273Methyl 2-bromo-2-(thiophen-3-yl)acetate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of (RS) methyl 2-hydroxy-2-(thien-3-yl)acetate (see Preparation 24) (4.49 g), triphenylphosphine (8.21 g) and carbon tetrabromide (10.4 g) in acetonitrile (100 ml) was refluxed for 2 hours, cooled, further triphenylphosphine (2.5 g) and carbon tetrabromide (3 g) were added, and refluxing was continued for a further 2 hours. After cooling, the mixture was used directly, without further purification, in Preparation 17.

후처리

  1. temperaturewas refluxed for 2 hours
  2. temperaturecooled
  3. temperaturerefluxing
  4. temperatureAfter cooling
  5. customthe mixture was used directly, without further purification, in Preparation 17

출처 및 근거

ORD 기록
ord-e9959afbf6454c56b25a8c56044ee553
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05171744

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