Water → Pyridine-2-carbothioamide

HRID 1682425

반응식

HRID 1682425 반응식
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].[NH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=O.O>O1CCCC1>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16](=[S:2])[NH2:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 150702-Pyridinecarboxamide

생성물 1

HCID 1549499Pyridine-2-carbothioamide수율 74.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

43 g of phosphorus pentasulfide were added slowly to 46.8 g of the amide of Stage A in 700 ml of tetrahydrofuran and the mixture was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water and extracted with ether. The extracts were dried and the solvent was evaporated under reduced pressure. After chromatography on silica (eluant: CH2Cl2 --AcOEt 8-2), 10 g of expected product melting at 137° C. were obtained.

후처리

  1. extractionextracted with ether
  2. customThe extracts were dried
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-189d08015cd14c07b7bc2532edc628c1
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05635485

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