Hydrochloric Acid → 1-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

HRID 1683729노트

반응식

HRID 1683729 반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:25]=[CH:24][C:7]([C:8](=[O:23])[CH2:9][N:10]2[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[N:12]3[CH2:19][CH2:20][CH2:21][N:22]=[C:11]23)=[CH:6][CH:5]=1.Cl>C(O)C>[OH:23][CH:8]([C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:25][CH:24]=1)[CH2:9][N:10]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]2[CH2:19][CH2:20][CH2:21][N:22]=[C:11]12

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 791782HCID 791782, 화합물HCID 4311764Sodium borohydride

생성물 1

HCID 28997651-(4-chlorophenyl)-2-(3,4-dihydropyrimido[1,2-a]benzimidazol-10(2H)-yl)ethanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Add 0.35 g (9.3 mmol) of sodium borohydride in small portions, with vigorous stirring, to a suspension of 3.0 g (9.3 mmol) of 10-(4-chlorophenacyl)-2,3,4,10-tetrahydropyrimidino[1,2-a]benzimidazole (obtained in Example 50) in 20 ml of ethanol. Maintain stirring for one hour and leave for 12 hours at room temperature. Acidify with hydrochloric acid, and evaporate the reaction mixture. Treat the residue with ammonium hydroxide and extract with chloroform. The organic phase obtained is passed over a column of alumina. Evaporate the solvent. The residue is the title compound.

후처리

  1. temperatureMaintain
  2. customleave for 12 hours at room temperature
  3. customevaporate the reaction mixture
  4. additionTreat the residue with ammonium hydroxide
  5. extractionextract with chloroform
  6. customThe organic phase obtained
  7. customEvaporate the solvent

출처 및 근거

ORD 기록
ord-1cbd5d10e6604fc8bd394ae2639bf8b0
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639756

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