Hydrogen Bromide → 2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid

HRID 1686424노트

반응식

HRID 1686424 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:13]([CH3:18])[C:14]([O:16]C)=[O:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Br>C(O)(=O)C.[OH-].[Na+]>[OH:2][C:3]1[CH:4]=[C:5]([CH:13]([CH3:18])[C:14]([OH:16])=[O:15])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

참가 물질

5

반응물 2

HCID 260Hydrogen BromideHCID 66734169Methyl 2-[3-methoxy-5-(trifluoromethyl)phenyl]propanoate

생성물 1

HCID 667340972-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid수율 70%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 14798Sodium Hydroxide용매

반응 조건

온도
100 °C

실험 절차

The product from step (ii) (0.8 g) was dissolved in glacial acetic acid (20 ml) and treated with 48% aqueous HBr (20 ml). The mixture was heated at 100° C. for 16 h. The mixture was cooled and diluted with 2M NaOH, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give an oil, which was purified by RPHPLC to give a colourless oil (0.5 g).

후처리

  1. temperatureThe mixture was cooled
  2. extractionextracted with ethyl acetate
  3. dry with materialdried (MgSO4)
  4. customevaporated under reduced pressure
  5. customto give an oil, which
  6. customwas purified by RPHPLC

출처 및 근거

ORD 기록
ord-9b82a0e8a97c492b9a6bc35743ac3cbc
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148572B2

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