Benzaldehyde → Benzaldehyde, 2,6-dichloro-, oxime

HRID 1689746

반응식

HRID 1689746 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=O.Cl.[NH2:12][OH:13].[OH-].[Na+].C(=O)C1C=CC=CC=1>O.CO>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[N:12][OH:13]

참가 물질

7

반응물 4

HCID 240BenzaldehydeHCID 67372,6-DichlorobenzaldehydeHCID 14798Sodium Hydroxide2회HCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 91328Benzaldehyde, 2,6-dichloro-, oxime

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

2,6-Dichloro-benzaldehyde (7.0 g, 40 mmol) and hydroxylamine hydrochloride (2.16 g, 44 mmol) are added to 10 mL of water and 30 mL of methanol. Sodium hydroxide (4.0 g, 100 mmol) is dissolved in 8 mL of water slowly. The sodium hydroxide solution is added to the benzaldehyde solution. The reaction is stirred overnight. The reaction mixture is partitioned between ethyl acetate and water. The organic layer is washed with brine and dried over solid sodium sulfate. The organic layer is filtered and the solvent is removed under reduced pressure to yield the title compound.

후처리

  1. customThe reaction mixture is partitioned between ethyl acetate and water
  2. washThe organic layer is washed with brine
  3. dry with materialdried over solid sodium sulfate
  4. filtrationThe organic layer is filtered
  5. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-91b4da23681b4de2a3466fc951868c49
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153624B2

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