Water → Benzaldehyde, 2,6-dichloro-, oxime

HRID 1689797

반응식

HRID 1689797 반응식
C(N(CC)CC)C.[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:10]=1[CH:11]=O.Cl.[NH2:19][OH:20].O>ClCCl>[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[C:10]=1[CH:11]=[N:19][OH:20]

참가 물질

6

반응물 4

HCID 962WaterHCID 67372,6-DichlorobenzaldehydeHCID 8471TriethylamineHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 91328Benzaldehyde, 2,6-dichloro-, oxime수율 132.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Alternate procedure: Add triethylamine (23.1 g, 229 mmol) dropwise to a solution of 2,6-dichloro-benzaldehyde (20.0 g, 114 mmol) and hydroxylamine hydrochloride (10.3 g, 149 mmol) in dichloromethane (200 mL). Stir the reaction mixture for 8 h. Add water (200 mL). Separate the phases and extract the aqueous phase with dichloromethane (100 mL). Wash the combined organic phases with water (100 mL). Concentrate the combined organic phases to provide 28.8 g (94%) of the title compound.

후처리

  1. customSeparate the phases
  2. extractionextract the aqueous phase with dichloromethane (100 mL)
  3. washWash the combined organic phases with water (100 mL)
  4. concentrationConcentrate the combined organic phases

출처 및 근거

ORD 기록
ord-868f23b784d94cea9d97e1fd57aa73cf
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153624B2

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