Methyl iodide → N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide

HRID 1694762

반응식

HRID 1694762 반응식
[Br:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[N:6][CH:7]=1.[C:14](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[Br:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([N:8]([CH3:14])[S:9]([CH3:12])(=[O:10])=[O:11])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 67280818N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide

생성물 1

HCID 67280607N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The product from step (i) (2.23 g), potassium carbonate (2.33 g) and methyl iodide (0.7 ml) were stirred in DMF (20 ml) for 20 h. The reaction was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane. Yield 1.5 g. Carried forward to step (ii) without characterisation.

후처리

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customThe residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane

출처 및 근거

ORD 기록
ord-162851ddd35c48c4be538806b1fc5bdf
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158820B2

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