Methyl iodide → N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide
반응식
[Br:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([NH:8][S:9]([CH3:12])(=[O:11])=[O:10])=[N:6][CH:7]=1.[C:14](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[Br:1][C:2]1[C:3]([CH3:13])=[CH:4][C:5]([N:8]([CH3:14])[S:9]([CH3:12])(=[O:10])=[O:11])=[N:6][CH:7]=1참가 물질
5
실험 절차
The product from step (i) (2.23 g), potassium carbonate (2.33 g) and methyl iodide (0.7 ml) were stirred in DMF (20 ml) for 20 h. The reaction was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane. Yield 1.5 g. Carried forward to step (ii) without characterisation.
후처리
- customThe reaction was quenched with water
- extractionextracted with EtOAc
- dry with materialdried (MgSO4)
- customevaporated
- customThe residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane
출처 및 근거
- ORD 기록
- ord-162851ddd35c48c4be538806b1fc5bdf
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08158820B2
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