Hydrochloric Acid → Methyl (4-chloro-2-iodophenoxy)acetate
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([I:9])=[C:6]([OH:8])[CH:7]=1.Br[CH2:11][C:12]([O:14][CH3:15])=[O:13].C(=O)([O-])[O-].[K+].[K+].[ClH:22]>C(#N)C>[Cl:22][C:3]1[CH:2]=[CH:7][C:6]([O:8][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[C:5]([I:9])[CH:4]=1참가 물질
6
실험 절차
A mixture of 5-chloro-2-iodophenol (4.95 g), methyl bromoacetate (1.85 ml) and potassium carbonate (2.79 g) in acetonitrile (20 ml) was heated under reflux for 2 h. Aq HCl was added and the mixture was extracted with ether (three times). The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol—ether as eluent) to give the sub-title compound (5.75 g).
후처리
- temperaturewas heated
- temperatureunder reflux for 2 h
- extractionthe mixture was extracted with ether (three times)
- dry with materialThe organic extracts were dried (MgSO4)
- customevaporated
- custompurified by chromatography (silica, petrol—ether as eluent)
출처 및 근거
- ORD 기록
- ord-30d0839d0b5342eea5331aedeb3431ea
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08163727B2
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