Propionitrile → 2-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile

HRID 1695182

반응식

HRID 1695182 반응식
[NH2:1][C:2]1[CH:6]=[CH:5]NN=1.CO[C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=1.[H-].[Na+].C(#N)CC>>[CH3:5][CH:6]([C:9](=[O:20])[C:10]1[CH:11]=[CH:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=1)[C:2]#[N:1]

참가 물질

5

반응물 4

HCID 7854PropionitrileHCID 24758Sodium hydrideHCID 520447Methyl 4-(trifluoromethyl)benzoateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 431572662-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)propionitrile수율 96%

실험 절차

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 4-trifluoromethyl-benzoic acid methyl ester (3.0 g, 14.7 mmol, 1.0 eq), NaH (1.2 g, 29.4 mmol, 2.0 eq) and propionitrile (4.9 mL, 69.4 mmol, 4.7 eq). The crude product was extracted with DCM and used in the following step without further purification (3.2 g, yield: 96%).

후처리

  1. customThe product was prepared
  2. extractionThe crude product was extracted with DCM
  3. customused in the following step without further purification (3.2 g, yield: 96%)

출처 및 근거

ORD 기록
ord-bd720de13d4141079f412edd57df2be6
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163729B2

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