Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate → Lithium benzomorpholine-2-carboxylate

HRID 1696292

반응식

HRID 1696292 반응식
O.[OH-].[Li+:3].[O:4]1[CH:9]([C:10]([O:12]CC)=[O:11])[CH2:8][NH:7][C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2>O.O1CCOCC1>[O:4]1[CH:9]([C:10]([O-:12])=[O:11])[CH2:8][NH:7][C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]1=2.[Li+:3]

참가 물질

5

반응물 2

HCID 31090Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylateHCID 168937Lithium hydroxide, monohydrate

생성물 1

HCID 69210254Lithium benzomorpholine-2-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
25 °C

실험 절차

A solution of lithium hydroxide monohydrate (1.43 g, 34.2 mmol) in water (50 mL) was added to a solution of ethyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (3.55 g, 17.1 mmol) in dioxane (50 mL), and the mixture was stirred at 25° C. for 21 h. The reaction mixture was concentrated to afford the title compound. MS m/z: 180 (M+1 of acid).

후처리

  1. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-895bb72e5b2d48cd8f87cbc0856bbb9c
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163766B2

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