4-Chlorophenyl Isocyanate → N-(4-Chlorophenyl)-N'-(3-formylphenyl)urea

HRID 1696614

반응식

HRID 1696614 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:18]=[O:19])=[CH:13][CH:12]=1>CN(C=O)C>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:1][C:2]2[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=[O:6])[CH:3]=2)=[O:19])=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 76934-Chlorophenyl IsocyanateHCID 74366Benzaldehyde, 3-amino-

생성물 1

HCID 71423985N-(4-Chlorophenyl)-N'-(3-formylphenyl)urea

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

a mixture of 360 mg of 3-aminobenzaldehyde (0.3 mmoles) and 460 mg of 4-chloro-phenylisocyanate (0.3 mmoles) in 3 ml of DMF is heated under microwave irradiation at 110° C. for 10 minutes. The precipitate formed is filtered giving the desired 1-(4-Chloro-phenyl)-3-(3-formyl-phenyl)-urea. Analytical LC/MS method A: ([M+H]+): 351, RT: 5.30 min (gradient 5 to 85% acetonitrile in 7 min).

후처리

  1. customThe precipitate formed
  2. filtrationis filtered

출처 및 근거

ORD 기록
ord-db28fdc86fd541bca671c216e2d4f2cd
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163768B2

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