Hydrochloric Acid → 1-(2,4-Dimethoxybenzyl)-6-fluoro-7-(2-furyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

HRID 1696910노트

반응식

HRID 1696910 반응식
[CH3:1][O:2][C:3]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][C:12]([F:21])=[C:13]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[N:14]=2)[C:9](=[O:22])[C:8]([C:23]([O:25]CC)=[O:24])=[CH:7]1.O.[OH-].[Li+].Cl>C1COCC1.O.[Cl-].[NH4+]>[CH3:1][O:2][C:3]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:4]=1[CH2:5][N:6]1[C:15]2[C:10](=[CH:11][C:12]([F:21])=[C:13]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[N:14]=2)[C:9](=[O:22])[C:8]([C:23]([OH:25])=[O:24])=[CH:7]1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67275183Ethyl 1-(2,4-dimethoxybenzyl)-6-fluoro-7-(2-furyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

생성물 1

HCID 672758741-(2,4-Dimethoxybenzyl)-6-fluoro-7-(2-furyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

시약·촉매·용매 3

HCID 962Water용매HCID 8028Tetrahydrofuran용매HCID 25517Ammonium Chloride용매

실험 절차

A solution of EXAMPLE 30A (166 mg) in THF (8 mL) was treated with lithium hydroxide monohydrate (155 mg) in water (7.4 mL), stirred at ambient temperature for 3 hours, diluted with 10% ammonium chloride (20 mL), adjusted to pH 3 with 1M HCl, and extracted with dichloromethane. The extract was dried (Na2SO4), filtered, and concentrated.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe extract was dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6197c48e01794bfba8cecf91563b4e96
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163769B2

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