Piperonal → Bis(3,4-methylenedioxy)chalcone

HRID 1698450

반응식

HRID 1698450 반응식
[CH:1]1[C:6]([CH:7]=[O:8])=[CH:5][C:4]2[O:9][CH2:10][O:11][C:3]=2[CH:2]=1.[CH3:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]2[O:21][CH2:22][O:23][C:17]=2[CH:16]=1)=O.[OH-].[Na+]>C(O)C>[CH2:22]1[O:21][C:18]2[CH:19]=[CH:20][C:15]([CH:13]=[CH:12][C:7]([C:6]3[CH:1]=[CH:2][C:3]4[O:11][CH2:10][O:9][C:4]=4[CH:5]=3)=[O:8])=[CH:16][C:17]=2[O:23]1

참가 물질

5

반응물 3

HCID 8438PiperonalHCID 14798Sodium HydroxideHCID 76622Acetopiperone

생성물 1

HCID 294346Bis(3,4-methylenedioxy)chalcone

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of piperonal (460 mg) and 3,4-methylenedioxyacetophenone (500 mg) in ethanol (20 ml) was treated with 1M NaOH solution (4 ml), then the mixture was stirred overnight. The pale yellow crystalline solid was filtered off, washed with water then cold aqueous ethanol and dried to give pure bis(3,4-methylenedioxy)chalcone DC-0006B (476 mg, 53%).

후처리

  1. filtrationThe pale yellow crystalline solid was filtered off
  2. washwashed with water
  3. dry with materialcold aqueous ethanol and dried

출처 및 근거

ORD 기록
ord-6e2fb4f5e95948368cd6489babc13cc7
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163957B2

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