Hydrochloric Acid → HCID 22387751, 화합물

HRID 1699878노트

반응식

HRID 1699878 반응식
Cl.C([O:4][C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)=[O:6])C.[OH-].[Na+].Cl>C(O)C>[ClH:25].[C:5]([C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[N:11]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=1[Cl:26])[CH2:10]2)([OH:6])=[O:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22388209HCID 22388209, 화합물

생성물 1

HCID 22387751HCID 22387751, 화합물수율 129.4%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
60 °C

실험 절차

6-(Ethoxycarbonyl)-3-(2,4-dichlorobenzyl)-3,4-dihydro-2-methylquinazoline hydrochloride (0.68 g) in a mixture of a 10% aqueous sodium hydroxide solution (5 ml) and ethanol (10 ml) was stirred at 60° C. for 1 hr. After standing cool the reaction mixture, concentrated hydrochloric acid (5 ml) was added and the precipitate was collected by filtration. The precipitated was washed with toluene and 2-propanol and dried to give the objective compound (0.41 g) as white crystals.

후처리

  1. additionwas added
  2. filtrationthe precipitate was collected by filtration
  3. washThe precipitated was washed with toluene and 2-propanol
  4. customdried

출처 및 근거

ORD 기록
ord-2ad808a9365641889d4ce5514cbede07
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06348474B1

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