Hydrochloric Acid → 3-(3-Methoxy-benzenesulfonylamino)-propionic acid

HRID 1700174노트

반응식

HRID 1700174 반응식
C([O:3][C:4](=[O:19])[CH2:5][CH2:6][NH:7][S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1)(=[O:10])=[O:9])C.[OH-].[Na+].Cl>CCO>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([S:8]([NH:7][CH2:6][CH2:5][C:4]([OH:19])=[O:3])(=[O:10])=[O:9])[CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 700249813-(3-Methoxy-benzenesulfonylamino)-propionic acid ethyl ester

생성물 1

HCID 186294403-(3-Methoxy-benzenesulfonylamino)-propionic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 3-(3-methoxy-benzenesulfonylamino)-propionic acid ethyl ester (5.62 g), prepared as described in Step F, in 200 mL of EtOH at room temperature was added 1N NaOH (20.54 mL). After stirring overnight, 1 N HCl solution was added until pH <5. The reaction was concentrated in vacuo to remove the EtOH, the residue partitioned between EtOAc and water, washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo to provide the title compound.

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customto remove the EtOH
  3. customthe residue partitioned between EtOAc and water
  4. washwashed with brine
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d194055d38c94fbea270701fa919440e
출처 데이터셋
uspto-grants-2002_02
특허 번호
US06350755B1

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