Propargyl alcohol → 3-Hydroxy-1-[4-chloro-2-benzoylphenyl]propyne

HRID 1701818노트

반응식

HRID 1701818 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:20][C:21]1[CH:22]=[CH:23][C:24](I)=[C:25]([CH:34]=1)[C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:27].[CH2:36]([OH:39])[C:37]#[CH:38]>[Pd](Cl)Cl.C(NCC)C>[OH:39][CH2:36][C:37]#[C:38][C:24]1[CH:23]=[CH:22][C:21]([Cl:20])=[CH:34][C:25]=1[C:26](=[O:27])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

참가 물질

6

반응물 3

HCID 7859Propargyl alcoholHCID 11776TriphenylphosphineHCID 129482625-Chloro-2-iodobenzophenone

생성물 1

HCID 128416443-Hydroxy-1-[4-chloro-2-benzoylphenyl]propyne

시약·촉매·용매 2

HCID 24290Palladium Chloride촉매HCID 8021Diethylamine용매

실험 절차

A mixture of 0.17 g (1.0 mmole) of palladium chloride, 0.5 g (2.0 mmole) of triphenylphosphine, 0.1 g (0.5 mmole) of cuprous iodide, 15 g (43 mmole) of 5-chloro-2-iodobenzophenone and 60 ml of diethylamine was stirred at room temperature for 20 min. In one portion 6.0 g (107 mmole) of propargyl alcohol was added, and the resulting mixture was stirred for 24 hr. The solvent was removed at reduced pressure and the residue was dissolved in ether. The ether solution was washed with water, dried with anhydrous sodium sulfate, and concentrated at reduced pressure to give the product as a red oil.

후처리

  1. stirringthe resulting mixture was stirred for 24 hr
  2. customThe solvent was removed at reduced pressure
  3. dissolutionthe residue was dissolved in ether
  4. washThe ether solution was washed with water
  5. dry with materialdried with anhydrous sodium sulfate
  6. concentrationconcentrated at reduced pressure

출처 및 근거

ORD 기록
ord-ed133d85e14f488683e8db2ba00900e8
출처 데이터셋
uspto-grants-1983_04
특허 번호
US04379090

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