Dimethyl Sulfate → N-methyl-1-(4-isopropylphenyl) ethylamine

HRID 1702958

반응식

HRID 1702958 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([NH2:12])[CH3:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+].S(OC)(O[CH3:19])(=O)=O>O>[CH3:19][NH:12][CH:10]([C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=1)[CH3:11]

참가 물질

5

반응물 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 37280391-(4-Isopropylphenyl)ethanamine

생성물 1

HCID 20120487N-methyl-1-(4-isopropylphenyl) ethylamine수율 69.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A suspension of 1-(4-isopropylphenyl) ethylamine (81 g) was stirred vigorously in a solution of sodium hydroxide (50 g) in water (250 ml) at room temperature. Dimethyl sulphate (64 g) was added dropwise to the stirred suspension over a period of 1 hour. The suspension was stored in a refrigerator overnight and three layers were formed. The top layer of organic material was extracted with ether and the ether solution was separated and dried over anhydrous magnesium sulphate. The ether was evaporated under reduced pressure to give a yellow oil which was distilled at a water pump to give N-methyl-1-(4-isopropylphenyl) ethylamine (61 g, 69%) colourless oil, boiling point 112° to 114° C./20 mm.

후처리

  1. customwas stored in a refrigerator overnight
  2. customthree layers were formed
  3. extractionThe top layer of organic material was extracted with ether
  4. customthe ether solution was separated
  5. dry with materialdried over anhydrous magnesium sulphate
  6. customThe ether was evaporated under reduced pressure
  7. customto give a yellow oil which
  8. distillationwas distilled at a water pump

출처 및 근거

ORD 기록
ord-3faef86d4e704d90bdf022d16c0a6523
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350644

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