Ammonium Acetate → N-(4-Hydroxyphenyl)glycine

HRID 1703061

반응식

HRID 1703061 반응식
O.[OH:2][C:3]1[CH:13]=[CH:12][C:6](C(O)C([O-])=O)=[CH:5][CH:4]=1.[Na+].[C:15]([O-:18])(=[O:17])[CH3:16].[NH4+:19]>O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([NH:19][CH2:16][C:15]([OH:18])=[O:17])=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 236981332-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate

생성물 1

HCID 67149N-(4-Hydroxyphenyl)glycine수율 67%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
125 °C

실험 절차

A mixture of sodium p-hydroxymandelate monohydrate (1.04 g.), ammonium acetate (2.0 g.) and water (0.5 ml.) is stirred and heated under reflux (internal temperature 125° C.) for 2.5 hours. Water (3 ml.) is added to the thick slurry thus obtained, the mixture is cooled and filtered and the solid residue is washed twice with water and then with acetone. There is thus obtained p-hydroxyphenylglycine (0.56 g., 66% yield).

후처리

  1. temperatureheated
  2. customthus obtained
  3. temperaturethe mixture is cooled
  4. filtrationfiltered
  5. washthe solid residue is washed twice with water

출처 및 근거

ORD 기록
ord-5199c7298b8e4d23b317a13a977cf9e7
출처 데이터셋
uspto-grants-1982_09
특허 번호
US04350826

연결된 노트

불러오는 중…