Butylbenzene → 4-Butyl-2'-fluorobenzophenone

HRID 1703581

반응식

HRID 1703581 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Cl-].[Al+3].[Cl-].[Cl-].[CH2:15]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]>C(=S)=S>[CH2:15]([C:19]1[CH:24]=[CH:23][C:22]([C:4]([C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])=[O:5])=[CH:21][CH:20]=1)[CH2:16][CH2:17][CH3:18]

참가 물질

5

반응물 3

HCID 7705ButylbenzeneHCID 98082-Fluorobenzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 473524-Butyl-2'-fluorobenzophenone수율 62.5%

시약·촉매·용매 1

HCID 6348Carbon Disulfide용매

실험 절차

A 3.16 g (0.02 mole) of 2-fluoro benzoic acid chloride was dissolved in 30 ml of carbon disulfide and then, 4.0 g (0.03 mole) of anhydrous aluminum chloride was added to the solution. A 2.68 g (0.02 mole) of n-butyl benzene was further added to the mixture with stirring, and the reaction was carried out at room temperature for 18 hours. In accordance with the process of Example 1, the reaction mixture was treated to obtain 3.2 g of 4-n-butyl-2'-fluorobenzophenone having a boiling point of 180° to 190° C./5 mmHg. (yield of 62.5%).

후처리

  1. additionIn accordance with the process of Example 1, the reaction mixture was treated

출처 및 근거

ORD 기록
ord-badff87eff144b81a28d22b3f4099785
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04124726

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