Potassium Hydroxide → 5-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

HRID 1704181노트

반응식

HRID 1704181 반응식
[CH2:1]([O:3][C:4](=O)[C@H:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[NH:6][C:7](=O)[CH3:8])[CH3:2].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16].[OH-].[K+]>C(Cl)(Cl)Cl>[CH3:8][C:7]1[S:16][C:4]([O:3][CH2:1][CH3:2])=[C:5]([CH2:10][CH:11]([CH3:13])[CH3:12])[N:6]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 14817Phosphorus sulfide (P2S5)HCID 1549286HCID 1549286, 화합물

생성물 1

HCID 227589445-Ethoxy-2-methyl-4-(2-methylpropyl)thiazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A one liter three-neck flask equipped with a stirrer, condenser, and heating mantle is charged with 31.4 g (0.156 mole) of N-acetylleucine ethyl ester, 34.7 g (0.156 mole) of phosphorus pentasulfide, and 250 ml of chloroform, and the mixture is heated under reflux for 24 hours while care is taken to exclude moisture. The reaction mixture is then cooled and made basic with 10% aqueous potassium hydroxide.

후처리

  1. customA one liter three-neck flask equipped with a stirrer, condenser
  2. temperatureheating mantle
  3. temperaturethe mixture is heated
  4. temperatureunder reflux for 24 hours while care
  5. temperatureThe reaction mixture is then cooled

출처 및 근거

ORD 기록
ord-5fe4ce41940e4c1d9dbd8a1d99c88bba
출처 데이터셋
uspto-grants-1978_11
특허 번호
USRE029843

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