Phenyl Isothiocyanate → N-[(4-Chlorophenyl)methyl]-N-cyclopentyl-N′-phenylthiourea

HRID 1704752

반응식

[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][NH:7][CH:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:15]1([N:21]=[C:22]=[S:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([CH:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[C:22]([NH:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[S:23])=[CH:13][CH:14]=1

참가 물질

반응물 2

HCID 7673Phenyl Isothiocyanate

HCID 8340834-chloro-N-cyclopentylbenzylamine

생성물 1

HCID 13018271N-[(4-Chlorophenyl)methyl]-N-cyclopentyl-N′-phenylthiourea수율 92.8%

실험 절차

Analogously to Example 1, 21 grams (0.1 mole) of N-4-chlorobenzyl-N-cyclopentylamine were reacted with 13.5 grams (0.1 mole) of phenylisothiocyanate. 32 grams of N-4-chlorobenzyl-N-cyclopentyl-N'-phenylthiourea were obtained. Yield: 92%, Melting point: 129°-132° C.

출처 및 근거

ORD 기록: ord-c45d45730c5d4b50b13b1fe0493dcdd3
출처 데이터셋: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04127673

연결된 노트

불러오는 중…