Mannitol → Sorbitol

HRID 1704794

반응식

HRID 1704794 반응식
C(C1C=CC(B([O-])[O-])=CC=1)=C.C(#N)C.COC(=O)C(C)=C.[CH2:22]([OH:33])[C@H:23]([C@H:25]([C@@H:27]([C@@H:29]([CH2:31][OH:32])[OH:30])[OH:28])[OH:26])[OH:24]>CO.O>[CH2:31]([OH:32])[C@H:29]([C@H:27]([C@@H:25]([C@@H:23]([CH2:22][OH:33])[OH:24])[OH:26])[OH:28])[OH:30].[OH:32][CH2:31][C@@H:29]([C@H:27]([C@@H:25]([C@@H:23]([CH2:22][OH:33])[OH:24])[OH:26])[OH:28])[OH:30].[CH2:22]([OH:33])[C@@H:23]([OH:24])[C@H:25]([OH:26])[C@H:27]([OH:28])[C@@H:29]([OH:30])[CH2:31][OH:32]

참가 물질

8

반응물 4

HCID 6251MannitolHCID 6342AcetonitrileHCID 6658Methyl MethacrylateHCID 22758913p-Vinylphenylboronate

생성물 3

HCID 5780SorbitolHCID 6251MannitolHCID 11850Galactitol

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

3,4; 5,6 -tri - 0 -(p-vinylphenylboronate), 12 ml acetonitrile, 4 ml methylmethacrylate 5.3 ml glycoldimethacrylate, and 75 mg azoisobutyronitrile (A I B N) are polymerized as described in example 1. The D-mannitol of the produced polymer is dissolved by treating the polymer in a column at 50° with a mixture of methanol/water 1:1. After eluting with 2 l of solvent during 24 hours more than 80 percent of D-mannitol are removed from the polymer. The polymer shows a good resolving power for the racemate D,L-mannitol. Furthermore one obtains good chromatographic separations between mannitol, sorbitol and dulcitol.

후처리

  1. additionby treating the polymer in a column at 50°
  2. washAfter eluting with 2 l of solvent during 24 hours more than 80 percent of D-mannitol
  3. customare removed from the polymer

출처 및 근거

ORD 기록
ord-bc424899e7cc4076a962ea3af672900f
출처 데이터셋
uspto-grants-1978_11
특허 번호
US04127730

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