Piperazine → 1-[2-(4-Pyridinyl)ethyl]piperazine

HRID 1707644

반응식

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH:7]([C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)=[CH2:8]>>[N:12]1[CH:13]=[CH:14][C:9]([CH2:7][CH2:8][N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 75024-Vinylpyridine

생성물 1

HCID 5586851-[2-(4-Pyridinyl)ethyl]piperazine수율 40.1%

실험 절차

To a melt of piperazine (15 g, 0.17 mol) heated to 105° C. was added dropwise 4-vinylpyridine (1.25 mL, 0.012 mol). After refluxing the reaction for 5.5 hours, it was cooled to room temperature and chromatographed to provide 0.92 g of the title compound.

후처리

temperatureAfter refluxing
customthe reaction for 5.5 hours
customchromatographed

출처 및 근거

ORD 기록: ord-d993ab5620a446f4b33f5a57a94925a0
출처 데이터셋: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05354747

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