Hydrochloric Acid → 2-Oxo-1,3-thiazolidine-5-carboxylic acid

HRID 1708207노트

반응식

HRID 1708207 반응식
[OH-:1].[Na+].Cl.[NH2:4][CH2:5][CH:6]([S:10][C:11](CC1C=CC=CC=1)=S)[C:7]([OH:9])=[O:8].Cl>C(O)C>[O:1]=[C:11]1[NH:4][CH2:5][CH:6]([C:7]([OH:9])=[O:8])[S:10]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86747702HCID 86747702, 화합물

생성물 1

HCID 189610442-Oxo-1,3-thiazolidine-5-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

12.0 ml of a 1N aqueous solution of sodium hydroxide were added to a suspension of 1.2 g of 3-amino-2-(benzylthiocarbonylthio)propionic acid hydrochloride in 35 ml of ethanol, and the resulting mixture was stirred at room temperature for 30 minutes, after which 12.0 ml of 1N aqueous hydrochloric acid were added, whilst ice-cooling. The solvent was then removed by distillation under reduced pressure, the resulting residue was dissolved in diethyl ether and the solution was dried over anhydrous magnesium sulfate. The solvent was then removed by distillation under reduced pressure, to give 0.50 g of a colorless powder. This powder was recrystallized from ethyl acetate, to give 0.25 g of the title compound as colorless columnar crystals, melting at 148°-150° C.

후처리

  1. temperaturecooling
  2. customThe solvent was then removed by distillation under reduced pressure
  3. dissolutionthe resulting residue was dissolved in diethyl ether
  4. dry with materialthe solution was dried over anhydrous magnesium sulfate
  5. customThe solvent was then removed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-970f3a2935644a62a014c0c0ba34424a
출처 데이터셋
uspto-grants-1994_10
특허 번호
US05356918

반응 노트

불러오는 중…