N-bromobutanimide → 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide

HRID 1711293

반응식

HRID 1711293 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C1C(=O)N([Br:23])C(=O)C1>C(Cl)Cl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:10])=[O:9])=[CH:4][C:3]=1[Br:23]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 8326274-Amino-N-(1,1-dimethylethyl)benzenesulfonamide

생성물 1

HCID 548502844-amino-3-bromo-N-tert-butyl-benzenesulfonamide수율 53.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-amino-N-tert-butyl-benzenesulfonamide (J. Med. Chem. (2003), 46(16), 3463-3475, 228 mg, 1.00 mmol) in DCM (10 mL), NBS (178 mg, 1.00 mmol) was added. The resulting mixture was stirred at RT for 30 min and washed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL). The organic layer was separated, dried and concentrated to obtain 4-amino-3-bromo-N-tert-butyl-benzenesulfonamide (163 mg, 53%).

후처리

  1. washwashed with satd NaHCO3 (10 mL) and 10% aq Na2S2O3 (10 mL)
  2. customThe organic layer was separated
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-82168f1fbbe246799a59bd1f0f3f1298
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790724B2

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