2,6-Diaminopyridine → N-(6-Aminopyridin-2-yl)-2,6-difluorobenzamide
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[N:3]=1.[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[C:11]=1[C:12](Cl)=[O:13]>O1CCOCC1>[NH2:8][C:4]1[N:3]=[C:2]([NH:1][C:12](=[O:13])[C:11]2[C:10]([F:9])=[CH:18][CH:17]=[CH:16][C:15]=2[F:19])[CH:7]=[CH:6][CH:5]=1참가 물질
4
실험 절차
Using a method similar to Preparation 48, using 2,6-diaminopyridine (2.6 g, 24 mmol), dioxane (75 mL), and 2,6-difluorobenzoyl chloride (1.4 g, 8 mmol) (stir at 25° C. for 16 hr.), gives the title intermediate (1.5 g, 75% yield): mass spectrum (ion spray): m/z=250.1 (M+1).
후처리
- customsimilar to Preparation 48
출처 및 근거
- ORD 기록
- ord-c3450ad10e3e4933af2f17642f4527ed
- 출처 데이터셋
- uspto-grants-2010_09
- 특허 번호
- US07803813B2
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