Chlorodifluoromethane → 3-Chloro-5-(difluoromethoxy)benzoic acid

HRID 1717463노트

반응식

HRID 1717463 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([OH:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[OH-].[Na+].Cl[CH:15]([F:17])[F:16]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:11][CH:15]([F:17])[F:16])[CH:10]=1)[C:5]([OH:7])=[O:6]

참가 물질

5

반응물 3

HCID 6372ChlorodifluoromethaneHCID 14798Sodium HydroxideHCID 130716463-Chloro-5-hydroxybenzoic Acid

생성물 1

HCID 219046063-Chloro-5-(difluoromethoxy)benzoic acid수율 75.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

3-Chloro-5-hydroxybenzoic acid (6.4 g, 37.2 mmol; see step (ii) above) dissolved in chloroform (200 mL) was transferred to a 500 mL three-necked round-bottomed flask fitted with a dry ice condenser and a gas inlet tube. Sodium hydroxide (100 mL, 5 M) was added and with vigorous stirring. Chlorodifluoromethane (Freon 22; 25 g, 290 mmol) was added portionwise through the gas inlet tube at ambient temperature. After 2 hours, the reaction was complete. Extractive work up gave 6.2 g, 28 mmol (yield: 75%) of the sub-title compound.

후처리

  1. customwas transferred to a 500 mL three-necked round-bottomed flask
  2. customfitted with a dry ice condenser and a gas inlet tube

출처 및 근거

ORD 기록
ord-b9154a40905142079176c5bff9f8737c
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07803954B2

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