2-(Diisopropylamino)ethyl chloride → 4-Diisopropylamino 2-(2-pyridyl)butyronitrile

HRID 1719676

반응식

HRID 1719676 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]#[N:9].Cl[CH2:11][CH2:12][N:13]([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15].[OH-].[Na+]>[Cl-].C([N+](C)(C)C)C1C=CC=CC=1.O>[CH:14]([N:13]([CH:17]([CH3:19])[CH3:18])[CH2:12][CH2:11][CH:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]#[N:9])([CH3:16])[CH3:15]

참가 물질

6

반응물 3

HCID 73122-(Diisopropylamino)ethyl chlorideHCID 14798Sodium HydroxideHCID 75959Pyridine-2-acetonitrile

생성물 1

HCID 133196744-Diisopropylamino 2-(2-pyridyl)butyronitrile

시약·촉매·용매 2

HCID 5963Benzyltrimethylammonium chloride촉매HCID 962Water용매

반응 조건

온도
35 °C

실험 절차

8 g of 2-pyridyl acetonitrile, 8.8 g of 1-chloro 2-diisopropylamino ethane and 0.27 g of benzyltrimethylammonium chloride are mixed, then, maintaining the temperature below 35° C., 35 ml of 50% sodium hydroxide solution are added. The mixture is heated to 35° C. for 5 hours. After cooling, it is diluted with water and extracted with ether. The organic phase is separated and dried over sodium sulfate, then the solvent is evaporated to dryness.

후처리

  1. additionare added
  2. temperatureAfter cooling
  3. extractionextracted with ether
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. customthe solvent is evaporated to dryness

출처 및 근거

ORD 기록
ord-1a2d2735dbf04a278e2ad804d8cd1815
출처 데이터셋
uspto-grants-1985_09
특허 번호
US04542134

연결된 노트

불러오는 중…