Glutaric anhydride → 5-Oxo-5-(4-pentylphenyl)pentanoic acid

HRID 1720138

반응식

HRID 1720138 반응식
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH2:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:10][CH2:11][CH2:12][CH3:13].[Cl-].[Al+3].[Cl-].[Cl-]>Cl>[CH2:9]([C:14]1[CH:15]=[CH:16][C:17]([C:5]([CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])=[O:6])=[CH:18][CH:19]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

참가 물질

5

반응물 3

HCID 7940Glutaric anhydrideHCID 10864PentylbenzeneHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 152955605-Oxo-5-(4-pentylphenyl)pentanoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Glutaric anhydride (10 g; 0.1mole) is reacted with pentylbenzene (100 ml) and aluminum chloride (29 g; 0.22 mole) at room temperature for 4 hours. The reaction mixture is poured into a mixture of ice-water (500 ml) and concentrated hydrochloric acid (50 ml) with vigorous stirring. The crude product is collected by filtration and recrystallized from aqueous ethanol to give 4-(4-n-pentylbenzoyl)butanoic acid (16.2 g) as colorless crystals, m.p. 104°-106° C.

후처리

  1. filtrationThe crude product is collected by filtration
  2. customrecrystallized from aqueous ethanol

출처 및 근거

ORD 기록
ord-1e697da2d277461f875d566082667c27
출처 데이터셋
uspto-grants-1996_04
특허 번호
US05504244

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