1-Hexanol → (R)-(+)-2,3-EPOXYPROPYL HEXYL ETHER
반응식
[CH2:1]([OH:7])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH-].[Na+].[CH2:10]([C@@H:12]1[O:14][CH2:13]1)Cl>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH2:1]([O:7][CH2:10][C@@H:12]1[O:14][CH2:13]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]참가 물질
6
실험 절차
6 ml of n-hexanol was added dropwise to a mixture of 40 g of sodium hydroxide, 24 g of (R)-epichlorohydrin as used in Synthetic Example 1 and 400 mg of tetra-butylammonium hydrogensulfate under cooling at 20° to 25° C. The reaction mixture was stirred for 3 hours at the same temperature, to which water was added. The product was extracted with ether, and the extract was purified by vacuum distillation to obtain 3.35 g of (R)-n-hexylglycidyl ether.
후처리
- temperatureunder cooling at 20° to 25° C
- additionwas added
- extractionThe product was extracted with ether
- distillationthe extract was purified by vacuum distillation
출처 및 근거
- ORD 기록
- ord-bbe72e1199e842d0a468806b6fce0083
- 출처 데이터셋
- uspto-grants-1996_04
- 특허 번호
- US05507975
반응 노트
불러오는 중…