Acetyl chloride → 1-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

HRID 1722930

반응식

HRID 1722930 반응식
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([S:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.C(N(CC)CC)C.[C:22](Cl)(=[O:24])[CH3:23].[OH-].[Na+]>C(Cl)Cl>[C:22]([N:6]1[C:2]([NH2:1])=[N:3][C:4]([S:7][CH2:8][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[N:5]1)(=[O:24])[CH3:23]

참가 물질

6

반응물 4

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

생성물 1

HCID 142551221-Acetyl-5-amino-3-benzylthio-1,2,4-triazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To 30 g (0.145 mol) 5-amino-3-benzylthio-1H-1,2,4-triazole and 25 ml triethylamine in 300 ml methylene chloride, 12.57 g (0.16 mol) acetyl chloride in 30 ml methylene chloride was added dropwise. It was then stirred at room temperature for 30 minutes, treated with 160 ml 1N caustic soda and the product extracted with methylene chloride. After drying it was recrystallised from ethyl acetate.

후처리

  1. extractionthe product extracted with methylene chloride
  2. customAfter drying it
  3. customwas recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-750e84dd79d44b36b62808683548c0fc
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04859231

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