Dimethyl Sulfoxide → 1-Methyl-3-(4-nitrophenyl)imidazolidin-2-one

HRID 1723487노트

반응식

HRID 1723487 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][NH:12][C:11]2=[O:15])=[CH:6][CH:5]=1)([O-:3])=[O:2].IC.[OH-].[K+].[CH3:20]S(C)=O>O>[CH3:20][N:12]1[CH2:13][CH2:14][N:10]([C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)[C:11]1=[O:15]

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodide2회HCID 14797Potassium Hydroxide2회HCID 3186721-(4-Nitrophenyl)imidazolidin-2-one

생성물 1

HCID 137323581-Methyl-3-(4-nitrophenyl)imidazolidin-2-one수율 74%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 21 parts of 1-(4-nitrophenyl)-2-imidazolidinone, 16 parts of iodomethane, 10 parts of potassium hydroxide and 200 parts of dimethyl sulfoxide was stirred for 3 hours at room temperature. Another portion of 16 parts of iodomethane and 10 parts of potassium hydroxide were added. Stirring was continued overnight. 300 Parts of water were added to the reaction mixture and the whole was stirred. The precipitated product was filtered off and crystallized from 4-methyl-2-pentanone, yielding 16.5 parts (74%) of 1-methyl-3-(4-nitrophenyl)-2-imidazolidinone; mp. 214.1°-215.5° C. (7).

후처리

  1. stirringStirring
  2. waitwas continued overnight
  3. stirringthe whole was stirred
  4. filtrationThe precipitated product was filtered off
  5. customcrystallized from 4-methyl-2-pentanone

출처 및 근거

ORD 기록
ord-b663efecce87450c9fca54dcbb50c18a
출처 데이터셋
uspto-grants-1989_08
특허 번호
US04861879

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