Hydrochloric Acid → (E)-2-[2-(4-Pyrrolidinobutoxyphenyl)ethenyl]benzothiazole

HRID 1723528노트

반응식

Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1/[CH:13]=[CH:14]/[C:15]1[S:16][C:17]2[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=2[N:19]=1.[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.Cl>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2/[CH:13]=[CH:14]/[C:15]2[S:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 31268Pyrrolidine

HCID 20025798HCID 20025798, 화합물

생성물 1

HCID 20025806(E)-2-[2-(4-Pyrrolidinobutoxyphenyl)ethenyl]benzothiazole수율 33%

실험 절차

The title compound was prepared in accordance with Example 38 starting with (H) of Example 38 (3.0 g, 8.7 mmol) and using pyrrolidine in place of dipropylamine to produce 1.1 g (33% yield) of the title compound as the HCl salt, mp 220°-222° C. IR(KBr): 3410, 1600 cm-1. MS: 379(MH+). 1H NMR (CD3OD): δ 8.02-6.91 (m, 10H), 4.12 (t, J=5.2 Hz, 2H), 3.23 (m, 6H), 2.54 (m, 4H), 2.21 (m, 4H).

출처 및 근거

ORD 기록: ord-f4147da308c24eea947ad7f5f89e5597
출처 데이터셋: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04861897

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