Water → Methyl 5-nitroquinoline-8-carboxylate

HRID 1725518

반응식

HRID 1725518 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2)([O-:3])=[O:2].IC.[C:19](=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:19][O:15][C:14]([C:11]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[C:5]2[C:10]=1[N:9]=[CH:8][CH:7]=[CH:6]2)=[O:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 154053315-Nitroquinoline-8-carboxylic acid

생성물 1

HCID 68521805Methyl 5-nitroquinoline-8-carboxylate수율 78.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 300 mg (1.375 mmol) of 5-nitroquinoline-8-carboxilic acid (Breckenridge, J. G. Et al., Canadian J. of Research Sect. B; 1947, 25, 49) in DMF (6 mL), 546 mg (3.850 mmol) of iodomethane and 190 mg (1.375 mmol) of potassium carbonate were added. The resulting mixture was stirred at room temperature for one hour. Water (10 mL) was added and the product collected by filtration. The residue was washed with water and dried to yield the title compound (250 mg, 78.4%).

후처리

  1. filtrationthe product collected by filtration
  2. washThe residue was washed with water
  3. customdried

출처 및 근거

ORD 기록
ord-5ee214cf2dbe45b78e8225f89264efb3
출처 데이터셋
uspto-grants-2009_02
특허 번호
US07491722B2

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