Trityl chloride → HCID 70604455, 화합물

HRID 1730313노트

반응식

HRID 1730313 반응식
[C:1](Cl)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][C:22]1([CH3:34])[S:26][C@@H:25]2[C@H:27]([NH2:30])[C:28](=[O:29])[N:24]2[C@H:23]1[C:31](O)=O.C([N:37](CC)CC)C>C(Cl)(Cl)Cl>[C:2]1([C:1]([NH:30][CH:27]2[C:28](=[O:29])[N:24]3[CH:23]([C:31]#[N:37])[C:22]([CH3:34])([CH3:21])[S:26][C@H:25]23)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 110826-Aminopenicillanic acid

생성물 1

HCID 70604455HCID 70604455, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Tritylchloride (61.2 g., 0.22 mole) is added to a mixture of 6-aminopenicillanic acid (43.3 g., 0.20 mole) and triethylamine (5.56 ml.)in chloroform (300 ml.) at about 5° C. The somewhat exothermic reaction is stirred and allowed to rise gradually to room temperature. It is stirred at room temperature for three days. Evaporation of the reactionmixture affords the title product which is used without purification.

후처리

  1. customat about 5° C
  2. customThe somewhat exothermic reaction
  3. customto rise gradually to room temperature
  4. stirringIt is stirred at room temperature for three days
  5. customEvaporation of the reactionmixture

출처 및 근거

ORD 기록
ord-60ee0b7ffdb844f98d0b8cddf91f57ec
출처 데이터셋
uspto-grants-1976_11
특허 번호
US03992394

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