Hydrochloric Acid → 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid

HRID 1731270

반응식

HRID 1731270 반응식
[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[C:8]([O:10]CC)=[O:9].[OH-].[K+].C(O)C.Cl>O>[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[C:8]([OH:10])=[O:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 2758821Ethyl 5-Chloro-1-methyl-1H-pyrazole-4-carboxylate

생성물 1

HCID 27357745-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester (13 grams, 0.07 mole) and potassium hydroxide (7.8 grams, 0.14 mole) were combined in 75 ml. of ethanol and refluxed for six hours. The solution was cooled, poured over water, acidified with concentrated hydrochloric acid, and the precipitated solid collected, dried, and recrystallized from water. The resulting 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid was obtained in the amount of 5.4 grams and melted at 195°-197° C.

후처리

  1. temperatureThe solution was cooled
  2. customthe precipitated solid collected
  3. customdried
  4. customrecrystallized from water

출처 및 근거

ORD 기록
ord-4250428618d14b3b878acef53985b60c
출처 데이터셋
uspto-grants-1986_11
특허 번호
US04620865

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