Hydrochloric Acid → 2-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide

HRID 1733147

반응식

HRID 1733147 반응식
[NH2:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8].[Cl:11][CH2:12][C:13](Cl)=[O:14].Cl>C1(C)C=CC=CC=1>[Cl:11][CH2:12][C:13]([NH:1][C:2]1[O:3][C:4]([CH3:10])=[C:5]([CH3:9])[C:6]=1[C:7]#[N:8])=[O:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrile

생성물 1

HCID 162273542-Chloro-N-(3-cyano-4,5-dimethyl-2-furanyl)acetamide수율 122.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

20.4 g (0.1 mole) of 2-amino-3-cyano-4,5-dimethylfurane and 17.5 g (0.155 mole) of chloroacetyl chloride were boiled in 200 ml of toluene until the evolution of hydrogen chloride had subsided. Thereafter, the solvent was evaporated off under reduced pressure and the residue was recrystallized from ethyl acetate. 26 g of 2-chloroacetylamino-3-cyano-4,5-dimethylfurane of melting point 114° C. were obtained in this manner.

후처리

  1. customThereafter, the solvent was evaporated off under reduced pressure
  2. customthe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-732f528106744e908873ac48e9d38c0e
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04240820

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