Pyridine → N-[4-(hexadecylamino)benzoyl]-2-methylalanine

HRID 1733504

반응식

HRID 1733504 반응식
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].N1C=CC=CC=1.Cl.[CH2:15]([NH:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]>O>[CH2:15]([NH:31][C:32]1[CH:33]=[CH:34][C:35]([C:36]([NH:1][C:2]([CH3:7])([C:3]([OH:5])=[O:4])[CH3:6])=[O:37])=[CH:39][CH:40]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6119Aminoisobutyric acidHCID 132553224-Hexadecylaminobenzoyl chloride hydrochloride

생성물 1

HCID 20437359N-[4-(hexadecylamino)benzoyl]-2-methylalanine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 5.24 g. of α-aminoisobutyric acid, 50 ml. of pyridine, and 25 ml. of H2O was stirred while 21.1 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride was added. The mixture was stirred for 18 hours at ambient temperature and filtered. The filtrate was evaporated and the residual yellow glass was dissolved in 1 N NaOH solution. The solution was extracted with diethyl ether and then acidified with 6 N HCl. The precipitate was collected, dried, and recrystallized from acetone, melting point 199°-202° C.

후처리

  1. additionA mixture of 5.24 g
  2. filtrationfiltered
  3. customThe filtrate was evaporated
  4. dissolutionthe residual yellow glass was dissolved in 1 N NaOH solution
  5. extractionThe solution was extracted with diethyl ether
  6. customThe precipitate was collected
  7. customdried
  8. customrecrystallized from acetone, melting point 199°-202° C.

출처 및 근거

ORD 기록
ord-a2a339dc721d4809a78cdb8ca5e5ee85
출처 데이터셋
uspto-grants-1980_12
특허 번호
US04242273

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